Job Details Level Experienced Job Location SmartLabs - Cambridge, MA Position Type Full Time Travel Percentage Negligible (Up to 10%) Job Shift Day Job Category Science Description Job Summary: We are seeking an experienced and highly skilled Senior Molecular Biologist with a strong background in structural biology to lead our research laboratory. The successful candidate will oversee and conduct advanced research projects focused on protein cloning, expression, purification, use of viral vectors and structural analysis. This is a leadership role that requires a deep understanding of molecular biology techniques, a track record of successful project management, and the ability to mentor and guide a team of scientists. Key Responsibilities: Laboratory Leadership: Lead and manage a team of scientists and technicians in the biochemistry lab. Develop and implement research strategies and experimental plans. Ensure the lab operates efficiently, adhering to safety protocols and best practices. Protein Cloning, Expression, and Purification: Design and optimize cloning strategies for the expression of recombinant proteins. Implement viral vectors to deliver genetic material to targeted cells. Oversee protein expression in various systems (e.g., bacterial, yeast, mammalian). Lead efforts in protein purification, including chromatography and other purification techniques. Structural Biology: Analyze and interpret structural data to guide protein engineering and functional studies. Collaborate with computational biologists to model and predict protein structures. Research and Development: Identify and pursue new research opportunities in molecular and structural biology. Stay current with advancements in the field and integrate new technologies into the lab. Publish research findings in peer-reviewed journals and present at scientific conferences when possible. Project Management: Manage multiple projects simultaneously, ensuring timelines and milestones are met. Coordinate with cross-functional teams, including bioinformatics, chemistry, and biophysics. Prepare progress reports and communicate results to stakeholders. Mentorship and Training: Provide training and mentorship to junior scientists and lab members. Foster a collaborative and innovative research environment. Evaluate and implement new techniques and methodologies in the lab. Qualifications Required: Ph.D. in Molecular Biology, Structural Biology, Biochemistry, or a related field. Minimum of 5-7 years of postdoctoral experience or equivalent industry experience. Proven expertise in protein cloning, expression, purification, and structural analysis. Hands-on experience with structural biology techniques such as Small Angle X-ray Scattering, X-ray crystallography, cryo-EM, or NMR. Strong publication record in peer-reviewed journals or patent literature. Experience in managing a laboratory, including budgeting, purchasing, and maintaining equipment. Excellent problem-solving skills and the ability to work independently and as part of a team. Strong communication skills, both written and verbal. Experience with mentoring and training junior scientists. Preferred: Experience in protein engineering and design. Knowledge of computational tools for structural analysis. Familiarity with high-throughput screening methods. Fluency in Japanese. Rigaku Americas
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